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Melittin (natural)

ALX-162-006

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PLA₂ activator

Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A₂ (PLA₂) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.

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Product Details

Appearance	White to faint tan powder.
CAS	20449-79-0
Formula	C₁₃₁H₂₂₉N₃₉O₃₁
MI	14: 5824
MW	2846.5
Purity	≥85% (HPLC)
Purity Detail	Phospholipase A2 impurity: <5 units per mg solid.
RTECS	OS3960000
Sequence	H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
Solubility	Soluble in PBS (5mg/ml) or water (5mg/ml).
Source	Isolated from bee venom.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Combined Effect of Melittin and DNase on Enterococcus faecalis Biofilms and Its Susceptibility to Sodium Hypochlorite: Ramaraj, S., Kim, M. A., et al.; Materials (Basel) 13, (2020), Abstract
Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-kappaB: M.H. Park, et al.; Prostate 71, 801 (2011), Abstract
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007), Abstract
Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds: D.J. Son, et al.; Pharmacol. Ther. 115, 246 (2007), Abstract
Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression: M. Wachinger, et al.; J. Gen. Virol. 79, 731 (1998), Abstract
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997), Abstract
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997), Abstract
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993), Abstract
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987), Abstract
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985), Abstract

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Melittin (natural)

ALX-162-006

Product Details

Handling & Storage

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