Melatonin

BML-NS520

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Endogenous agonist at melatonin MT1 and MT2 receptors. Displays antioxidant and antiapoptotic effects in numerous cell types as well as beneficial effects in various neurodegenerative diseases. It protects neuronal cells from amyloid beta-mediated oxidative damage and increases survival in an Alzheimer’s disease transgenic mouse model. Melatonin directly inhibits mitochondrial permeability transition pore (IC₅₀ = 0.8M) and reduced the loss of neurons in a rat model of transient brain ischemia.

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Product Details

Alternative Name	N-Acetyl-5-methoxytryptamine
Appearance	White to off-white powder.
CAS	73-31-4
Couple Target	Melatonin receptor, MPTP
Couple Type	Inhibitor, Ligand
Formula	C₁₃H₁₆N₂O₂
MI	14: 5816
MW	232.3
Purity	≥98% (HPLC)
RTECS	AC5955000
Solubility	Soluble in dilute aqueous acid, methanol or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding: W.G. Deng, et al.; Blood 108, 518 (2006), Abstract
Melatonin and nitric oxide: S. Aydogan, et al.; J. Endocrinol. Invest. 29, 281 (2006), (Review), Abstract
Melatonin inhibits endothelial nitric oxide production in vitro: E.K. Tamura, et al.; J. Pineal. Res. 41, 267 (2006), Abstract
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin: S.A. Andrabi, et al.; FASEB J. 18, 869 (2004), Abstract
Mitochondrial regulation by melatonin and its metabolites: D. Acuna-Castroviejo, et al.; Adv. Exp. Med. Biol. 527, 549 (2003), (Review), Abstract
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease: E. Matsubara, et al.; J. Neurochem. 85, 1101 (2003), Abstract
Melatonin protects against ischemia-reperfusion injury and inhibits apoptosis in isolated working rat heart: P. Dobsak, et al.; Patophysiology 9, 179 (2003), Abstract
Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells: Y.M. Yoo, et al.; J. Pineal. Res. 33, 146 (2002), Abstract
Nitrosation of melatonin by nitric oxide and peroxynitrite: B. Blanchard, et al.; J. Pineal. Res. 29, 184 (2000), Abstract
Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington’s disease, Alzheimer’s disease and parkinsonism: R.J. Reiter, et al.; Ann. N.Y. Acad. Sci. 890, 471 (1999), Abstract

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Melatonin

BML-NS520

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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