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Melanoma marker (human) monoclonal antibody (HMB45)

ENZ-C34930

22 citations

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This antibody is covered by our Worry-Free Guarantee.

Melanoma marker (human) monoclonal antibody (HMB45) Immunohistochemistry — Figure 2: Immunohistochemistry analysis of human melanoma skin tissue using Melanoma marker (human) mAb (HMB45), (Prod. No. ENZ-C34930) at a dilution of 1:20.

Product Details

Application	IHC (PS)
Clone	HMB45
Crossreactivity	Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors.
Formulation	Liquid. In PBS containing 0.1% sodium azide and 1% BSA.
Host	Mouse
Immunogen	Human axillary lymph node tissue containing pigmnted melanoma metastases.
Isotype	IgG1
Purity Detail	Affinity purified.
Recommendation Dilutions/Conditions	Immunohistochemistry (paraffin sections; this antibody can be used for staining of paraffin-embedded tissue sections fixed in neutral buffered formalin and is compatible with most commonly used histological fixatives. Choose a good quality enzyme-linked anti-mouse IgG1 antibody for detection). A 20- to 50-fold dilution of the antibody is suggested. Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually.
Source	Purified from ascites.
Species Reactivity	Human
Specificity	Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors.
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks: Schmid, R., Schmidt, S. K., et al.; Mater. Today Bio 26, 101071 (2024), Abstract
The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation: Ho, T., Watt, B., et al.; J. Biol. Chem. 291, 3595 (2016), Abstract
Unusual manifestations of secondary urothelial carcinoma: C.L. Zhao, et al.; Human Pathology: Case Reports 3, 1 (2016), Application(s): Immunohistochemical antibodies used for diagnosis of cases
Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma: S. Yamada, et al.; World J. Gastroenterol. 21, 1349 (2015), Application(s): Immunohistochemistry, Abstract — Full Text
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.: Tüting, T., Davidson, I., et al.; Nat. Commun. 6, 8755 (2015), Application(s): IHC / Reactant(s): Human, Mouse, Abstract
Sclerosing Epithelioid Fibrosarcoma of the Kidney: Clinicopathologic and Molecular Study of a Rare Neoplasm at a Novel Location: C.H. Ohlmann, et al.; Ann. Diagn. Pathol. 19, 221 (2015), Application(s): Immunohistochemistry, Abstract
SRC kinase is a novel therapeutic target in lymphangioleiomyomatosis: Tyryshkin, A., Bhattacharya, A., et al.; Cancer Res. 74, 1996 (2014), Abstract
Ebselen is a new skin depigmenting agent that inhibits melanin biosynthesis and melanosomal transfer: B. Kasraee, et al.; Exp. Dermatol. 21, 19 (2012), Application(s): ICC on Melanoma cell line (B16); IHC on epidermis., Abstract
Loss of S100 antigenicity in metastatic melanoma: Aisner, D. L., Maker, A., et al.; Hum. Pathol. 36, 1016 (2005), Abstract
Melanoma cells secrete follistatin, an antagonist of activin-mediated growth inhibition: Stove, C., Vanrobaeys, F., et al.; Oncogene 23, 5330 (2004), Abstract

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Melanoma marker (human) monoclonal antibody (HMB45)

ENZ-C34930

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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