Mdivi-1

BML-CM127

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Inhibitor of mitochondrial division

Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (<5 min) reversible and dose-dependent formation of net-like mitochondria in wild-type cells with an IC₅₀= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1. It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC₅₀ of 1-10µM but is not a general inhibitor of GTPases.

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Product Details

Appearance	White solid.
CAS	338967-87-6
Couple Target	Dynamin, MPTP
Couple Type	Inhibitor
Formula	C₁₅H₁₀Cl₂N₂O₂S
Identity	Determined by 1H-NMR.
MW	353.2
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Mitochondrial OPA1 deficiency is associated to reversible defects in spatial memory related to adult neurogenesis in mice: T. Andraini, et al.; eNeuro 10, ENEURO.0073-23.2023 (2023), Abstract
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells: Ojha, R., Tantray, I., et al.; Dev. Cell 57, 260 (2022), Abstract
Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival: Y. Song, et al.; Autophagy 1080, 15548627 (2021), Abstract
Mitochondrial OPA1 deficiency causes reversible defects in adult neurogenesis-associated spatial memory in mice: Andraini, T., Moulédous, L., et al.; bioRxiv , (2021)
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages: Boytard, L., Hadi, T., et al.; Nat. Commun. 11, 4311 (2020), Abstract
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract — Full Text
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson’s disease model: J.E. Bae, et al.; Cell Death Dis. 10, 952 (2019), Abstract — Full Text
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells: A. Hogue, et al.; Cell Death Discov. 4, 39 (2018), Abstract — Full Text
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction: Y.S. Park, et al.; Toxicol. Lett. 284, 120 (2017), Abstract
Effect of mitochondrial fission inhibition on C2C12 differentiation: D. Bloemberg, et al.; Data Brief 7, 634 (2016), Application(s): Cell culture, Abstract — Full Text

Last modified: May 29, 2024

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Mdivi-1

BML-CM127

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