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MDA5 and RIG-I are highly conserved helicases involved in the innate immune response to virus. MDA-5 ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. After binding nonself-ligand, RIG-I and MDA5 interact via their CARD domains with the signaling-adaptor molecule, IPS-1 (also known as MAVS, VISA and Cardif), which leads to the induced expression of IFN-β, IRF3-target genes and NF- κB target genes to drive antiviral and inflammatory responses.
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| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Alternative Name | Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2 |
|---|---|
| Application | IP, WB |
| Host | Rabbit |
| Species Reactivity | Human |
| Alternative Name | Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2 |
|---|---|
| Application | ELISA, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human, Mouse |
| Alternative Name | Helicard, Melanoma differentiation-associated gene 5, Interferon-induced helicase C domain-containing protein 1, RH116, CADM-140 autoantigen, RIG-I-like receptor 2, RLR-2 |
|---|---|
| Application | ELISA, IF, IHC (PS), WB |
| Host | Rabbit |
| Isotype | IgG |
| Species Reactivity | Human, Mouse |