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MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs recognize different pathogen-associated molecular patterns, thereby linking the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS.
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Immunohistochemistry analysis of rat spleen cells using MD-2 antibody at 2µg/ml.
Western blot analysis of MD-2 in mouse spleen cell lysate with MD-2 antibody at 1µg/ml.
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RUO – Research Use Only |
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