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HDAC1 inhibitor

Inhibitor of histone deacetylase 1 (HDAC1) (IC₅₀= 4.5µM) and maize histone deacetylase HD2 (IC₅₀=1.9µM).

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Alternative Name	3-(4-Toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Appearance	Off-white powder.
Couple Target	HDAC, HDAC1, HDAC2
Couple Type	Inhibitor
Formula	C₁₆H₁₆N₂O₃
Identity	Determined by 1H-NMR.
MW	284.3
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response: Ueda, M., Matsui, A., et al.; Plant Physiol. 175, 1760 (2017), Abstract
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation: A. Mai, et al.; J. Med. Chem. 45, 1778 (2002), Abstract
3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors: S. Massa, et al.; J. Med. Chem. 44, 2069 (2001), Abstract

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