MAZ51

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VEGFR-3 inhibitor

Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC₅₀=1µM).

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Alternative Name	3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one
Appearance	Orange crystals.
CAS	163655-37-6
Couple Target	VEGFR
Couple Type	Inhibitor
Formula	C₂₁H₁₈N₂O
Identity	Identity determined by MS, 1H- and 13C-NMR.
MW	314.4
Purity	≥98%
Solubility	Soluble in DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression: A.R. Harris, et al.; BMC Cancer 18, 718 (2018), Abstract — Full Text
Lysophosphatidic acid up-regulates vascular endothelial growth factor-C and lymphatic marker expressions in human endothelial cells: C.I. Lin, et al.; Cell. Mol. Life Sci. 65, 2740 (2008), Application(s): tube formation and lymphatic marker expression studies on HUVECs, Abstract
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo: V. Kirkin, et al.; Int. J. Cancer 112, 986 (2004), Application(s): proliferation assays in vivo and on primary human and tumor cell lines, Abstract — Full Text
Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2: V. Kirkin, et al.; Eur. J. Biochem. 268, 5530 (2001), Abstract

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