Matrix Metalloproteinase-10 (MMP-10) fluorometric drug discovery kit

A QUANTIZYME^® Assay System. The MMP-10 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-10 (MMP-10, stromelysin-2) using a quenched fluorogenic peptide: OMNIMMP^® fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. Also included are active enzyme, a prototypic control inhibitor (NNGH³), and a detailed instruction booklet.