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- Highly active serine protease providing superior results.
- Potent negative regulator of hepcidin.
- Eukaryotic cell-derived protein guarantees proper PTM.
Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis.
Matriptase-2 plays an important role in understanding iron disorders; including various anemias and iron overload conditions, affecting millions of people worldwide.
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RUO – Research Use Only |
|---|
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| Alternative Name | MT-SP1, Membrane-type serine protease 1, ST14, Suppression of tumorigenicity protein 14, TADG-15, Tumor-associated differentially expressed gene 15 protein, SNC19 |
|---|---|
| Purity | ≥98% (SDS-PAGE) |
| Source | Recombinant human matriptase (aa 596-855) fused at the N-terminus to a His-tag. |