Manoalide

BML-EI177

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Phospholipase inhibitor

Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A₂ (PLA₂, IC₅₀=0.02-0.2µM depending on substrate) as well as bee (IC₅₀=0.05µM) and cobra venom (IC₅₀=2µM) PLA₂by covalently modifying lysine residues. Inhibits human recombinant sPLA₂ (IC₅₀=4.7µM) selectively over cPLA₂. Also inhibits phospholipase C (PLC, IC₅₀=1.5µM) and Ca²⁺ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.

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Product Details

Appearance	Colorless to pale waxy or filmy residue.
CAS	75088-80-1
Couple Target	Calcium channel, Phospholipase, PLA, PLC
Couple Type	Inhibitor
Formula	C₂₅H₃₆O₅
MW	416.6
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract
Quorum Sensing Antagonism from Marine Organisms: M.E. Skindersoe, et al.; Mar. Biotechnol. (NY) 10, 56 (2008), Abstract
Manoalide: A. Soriente, et al.; Curr. Med. Chem. 6, 415 (1999), Review, Abstract
Effect of manoalide on human 5-lipoxygenase activity: F. Cabre, et al.; Inflamm. Res. 45, 218 (1996), Abstract
Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide: I.D. Bianco, et al.; Biochim. Biophys. Acta 1250, 197 (1995), Abstract
Phospholipase A2 activation in cultured mouse hepatocytes exposed to tumor necrosis factor-alpha: G.M. Adamson, et al.; J. Biochem. Toxicol. 9, 181 (1994), Abstract
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia: A.M. Mayer & J.A. Spitzer; J. Pharmacol. Exp. Ther. 267, 400 (1993), Abstract
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W. C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation: L.J. Reynolds, et al.; J. Biol. Chem. 266, 16512 (1991), Abstract — Full Text
Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide: P.B. Jacobson, et al.; Biochem. Pharmacol. 39, 1557 (1990), Abstract

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Manoalide

BML-EI177

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