Magnolol

ALX-350-352

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Antitumor and anti-angiogenic agent

Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC₅₀=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).

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Product Details

Alternative Name	5,5’-Diallyl-2,2’-biphenyldiol
Appearance	White to light yellow powder.
CAS	528-43-8
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₁₈H₁₈O₂
MI	14: 5697
MW	266.3
Purity	≥98% (HPLC)
RTECS	DV5105500
Solubility	Soluble in DMSO, 100% ethanol or methanol.
Source	Isolated from Magnolia officinalis.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007), Abstract — Full Text
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006), Abstract — Full Text
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003), Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000), Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998), Abstract
Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983), Abstract

Related Products

Honokiol

ALX-350-350

iNOS inhibitor

9 citations

Alternative Name	5,3’-Diallyl-2,4’-biphenyldiol, 5,3’-Diallyl-2,4’-dihydroxydiphenyl
CAS	35354-74-6
Couple Type	Inhibitor
Purity	≥98% (HPLC)

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Magnolol

ALX-350-352

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