M344

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HDAC inhibitor

Potent inhibitor of histone deacetylases (HDACs) (IC₅₀≤1µM).

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Alternative Name	4-Dimethylamino-N-(6-hydroxycarbamoylhexyl)-benzamide
Appearance	White crystalline solid.
CAS	251456-60-7
Couple Target	HDAC
Couple Type	Inhibitor
Formula	C₁₆H₂₅N₃O₃
Identity	Determined by NMR.
MW	307.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (1mg/ml)

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB: Ying, H., Zhang, Y., et al.; PLoS One 7, e48832 (2012), Abstract
Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation: M. Jung, et al.; J. Med. Chem. 42, 4669 (1999), Abstract

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