M1 TUBE (FLAG)

LifeSensors has developed TUBE (Tandem Ubiquitin Binding Entity) technology for the detection, characterization and isolation of polyubiquitylated proteins from cells and tissue extracts. TUBEs capitalize on the linkage of multiple ubiquitin interacting motifs (UIMs) to generate reagents with high affinity for polyubiquitin.TUBEs have 100 to 1000-fold higher affinity for polyubiquitin chains compared to monomer ubiquitin binding domains (UBDs). TUBEs both stabilize and bind to ubiquitylated proteins, serving as an indispensable tool for ubiquitologists. Our versatile collection of TUBEs includes reagents for the isolation/pulldown of polyubiquitin conjugates include both linkage-specific and non-specific reagents including Anti-M1 (Linear) TUBE, Anti-K63 TUBE, Anti-K48 TUBE, and the non-specific reagents Anti-Ubiquitin TUBE1 and TUBE2.