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Lysophosphatidic acid

BML-LP100

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LPA receptor ligand

Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons.

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Product Details

Alternative Name	1-Oleoyl-lysophosphatidic acid . sodium salt
Appearance	Waxy solid.
CAS	325465-93-8
Couple Target	LPA receptor
Couple Type	Ligand
Formula	C₂₁H₄₀O₇P . Na
MW	458.5
Purity	≥98% (TLC)
Solubility	Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

RP11-40C6.2 Inactivates Hippo Signaling by Attenuating YAP1 Ubiquitylation in Hepatitis B Virus-associated Hepatocellular Carcinoma: Zhuo, H., Wu, C., et al.; J. Clin. Transl. Hepatol. 11, 323 (2023), Abstract
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis: Darp, R., Vittoria, M. A., et al.; Nat. Commun. 13, 4109 (2022), Abstract
RP11-323N12.5 promotes the malignancy and immunosuppression of human gastric cancer by increasing YAP1 transcription: Wang, J., Huang, F., et al.; Gastric Cancer 24, 85 (2021), Abstract
HPV E6 Protein Associated SOX21-AS1 Promotes YAP/TAZ Activation by Attenuating YAP1 Ubiquitination in Humannbsp;Cervical Cancer: Liu, Q., Zhu, Z., et al.; Research Square , (2020)
Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1: Zhang, X., Liu, P., et al.; J. Cancer 11, 479 (2020), Abstract
LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2: J, Park, et al.; Cell. Signal. 44, 138 (2018), Abstract
A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration: Y. Fukano, et al.; Biochem. Biophys. Res. Commun. 478, 624 (2016), Application(s): Responses of mouse microglial MG5 cells toward GPCR ligands, Abstract
Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3: J.P. Mansell, et al.; Biochimie 128-129, 193 (2016), Application(s): Treatment with human osteoblast-like cells (MG63), Abstract
Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells: Y.S. Hwang, et al.; J. Cancer Prev. 20, 121 (2015), Application(s): Cell Culture, Abstract — Full Text
Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton: McNary, S. M., Athanasiou, K. A., et al.; Tissue Eng. Part A 20, 921 (2014), Abstract

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Lysophosphatidic acid

BML-LP100

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Handling & Storage

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