LY2090314

Wnt/β-catenin pathway activator. LY2090314 is a highly potent and selective inhibitor of glycogen synthase-3-kinase (GSK-3). It stabilized β-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts. LY2090314 significantly reduced growth in multiple neuroblastoma cell lines. It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.