LY-83,583

ALX-550-002

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Guanylyl cyclase inhibitor

Competitive inhibitor of soluble guanylyl cyclase (sGC) (IC₅₀=2µM) and of cGMP production. Neurotoxin. Blocks antigen-induced leukotriene release and reduces platelet-endothelial cell adhesion. Blocks acethylcholine-induced vasorelaxation.

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Product Details

Alternative Name	6-(Phenylamino)-5,8-quinolinedione, 6-Anilino-5,8-quinolinedione
Appearance	Violet to dark red powder.
CAS	91300-60-6
Couple Target	Guanylyl cyclase
Couple Type	Inhibitor
Formula	C₁₅H₁₀N₂O₂
Identity	Determined by 1H-NMR.
MW	250.3
Purity	≥95% (TLC)
Solubility	Soluble in methanol, methylene chloride or diluted aqueous acid; insoluble in water.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Short- and Long-Term Effects of UVA on Arabidopsis Are Mediated by a Novel cGMP Phosphodiesterase: Isner, J. C., Olteanu, V. A., et al.; Curr. Biol. 29, 2580 (2019), Abstract
The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats: A.C. Ribeiro & L. Kapas; Brain Res. 1049, 25 (2005), Abstract
Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia: H.Y. Koh and J.W. Jacklet; J. Neurosci. 19, 3818 (1999), Abstract — Full Text
LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels: R.K. Prasad, et al.; Eur. J. Pharmacol. 366, 101 (1999), Abstract
Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation: T.H. Murphy, et al.; J. Neurochem. 70, 2156 (1998), Abstract
Inhibition of nitric oxide formation and superoxide generation during reduction of LY83583 by neuronal nitric oxide synthase: Y. Kumagai, et al.; Eur. J. Pharmacol. 360, 213 (1998), Abstract
Guanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts: R.E. Klabunde, et al.; Cardiovasc. Res. 37, 676 (1998), Abstract
A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes: N. Abi-Gerges, et al.; Br. J. Pharmacol. 121, 1369 (1997), Abstract
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit: T. Kawada, et al.; Gen. Pharmacol. 25, 1361 (1994), Abstract
Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells: D. Beasley, et al.; J. Clin. Invest. 87, 602 (1991), Abstract

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LY-83,583

ALX-550-002

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