LY 171883

BML-RA101

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Leukotriene D₄ antagonist

Selective, orally active leukotriene D₄ antagonist. Has been shown to bind to the γ-isoform of the peroxisome proliferator-activated receptor (PPARγ).

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Product Details

Alternative Name	Tomelukast
Appearance	White solid.
CAS	88107-10-2
Couple Target	Leukotriene, PPAR, Prostanoid receptor
Couple Type	Inhibitor, Ligand
Formula	C₁₆H₂₂N₄O₃
MW	318.4
MeltingPoint	117-119°C
Purity	≥90% (HPLC)
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or dimethyl formamide. Also soluble in 0.5M aqueous sodium bicarbonate.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Organic stock solutions are stable for at least six months when stored at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma: B.M. Forman, et al.; Cell 83, 803 (1995), Abstract
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor: P. Tontonoz, et al.; Cell 79, 1147 (1994), Abstract
Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit: A. Sala, et al.; Br. J. Pharmacol. 110, 1206 (1993), Abstract
In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist: D.W. Snyder, et al.; J. Pharmacol. Exp. Ther. 243, 548 (1987), Abstract
LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 233, 148 (1985), Abstract

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LY 171883

BML-RA101

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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