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Lucigenin

ALX-620-061

12 citations

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ROS dye

Chemiluminescent probe for the detection of superoxide in biological systems.

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Product Details

Alternative Name	bis-N-Methylacridinium nitrate, N,N’-Dimethyl-9,9′-biacridinium dinitrate
Appearance	Off-white to brown powder.
CAS	2315-97-1
Formula	C₂₈H₂₂N₄O₆
MW	510.5
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (~12mg/ml), 100% ethanol (~0.5mg/ml) or acetic acid (~10mg/ml, heat up solution).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Human CD4+CD25+ T cells expressing a chimeric antigen receptor against aberrant superoxide dismutase 1 trigger antigen-specific immunomodulation: D.J. Graber, et al.; Cytotherapy 26, 126 (2024), Abstract
PKC/NADPH oxidase are involved in the protective effect of pioglitazone in high homocysteine-induced paracrine dyfunction in endothelial progenitor cells: S. Xu, et al.; Am. J. Transl. Res. 9, 1037 (2017), Abstract — Full Text
Globular adiponectin attenuates LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling: A. Shrestha & P.H. Park; Life Sci. 148, 71 (2016), Application(s): Cell culture, Abstract
Crucial Role of Membrane Type 1 Matrix Metalloproteinase (MT1- MMP) in RhoA/Rac1-Dependent Signaling Pathways in Thrombin- Stimulated Endothelial Cells: K. Ando, et al.; J. Atheroscler. Thromb. 18, 762 (2011), Abstract — Full Text
In retinal vein occlusion platelet response to thrombin is increased: G. Leoncini, et al.; Thromb Res. 124, e48 (2009), Abstract
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production: M.P. Skatchkov, et al.; BBRC 254, 319 (1999), Abstract
Lucigenin is a mediator of cytochrome C reduction but not of superoxide production: I.B. Afanas’ev, et al.; Arch. Biochem. Biophys. 366, 267 (1999), Abstract
Lucigenin as a substrate of microsomal NAD(P)H-oxidoreductases: I.A. Schepetkin; Biochemistry (Mosc.) 64, 25 (1999), Abstract
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999), Abstract
Lucigenin as mediator of superoxide production: revisited: S.I. Liochev & I. Fridovich; Free Radic. Biol. Med. 25, 926 (1998), Abstract

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Lucigenin

ALX-620-061

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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