LPS from Salmonella minnesota R345 (Rb) (TLRGRADE^®) (Ready-to-Use)

Strong activator of Toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.

Lipopolysaccharide from Salmonella minnesota R345 (Rb)

TLR, TLR4

Activator, Ligand

Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.

Absence of detectable protein or DNA contaminants with agonistic TLR activity.

Rough (R)-form LPS, isolated and purified from Salmonella minnesota R345 (Rb mutant) by a modification of the PCP extraction method, converted to the uniform sodium salt form and dissolved in sterile pyrogen-free double distilled water.