Home Shop LPS from E. coli, Serotype O55:B5 (TLRGRADE®) (Ready-to-Use)

LPS from E. coli, Serotype O55:B5 (TLRGRADE^®) (Ready-to-Use)

ALX-581-013

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TLR4 activator

Potent activator of TLR 4
TLR4-specific activation as shown in TLR4-deficient cells
Convenient and stable ready-to-use solution
Highly cited

TLRGRADE® LPS is commonly used to active TLR4, trigger inflammatory signaling, and co-stimulate the immune response, both in vitro and in vivo.

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Product Details

Alternative Name	Lipopolysaccharide from E. coli, Serotype O55:B5 S-form
Couple Target	TLR, TLR4
Couple Type	Activator, Ligand
Formulation	Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
Purity	Absence of detectable protein or DNA contaminants with agonistic TLR activity.
Source	Smooth (S)-form LPS isolated and purified from E. coli 055:B5 by a modification of the phenol water extraction and PCP extraction method, converted to the uniform sodium salt form and dissolved in sterile pyrogen-free double distilled water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +4°C.
Handling	Do not ingest. Wear gloves and mask when handling this product! Avoid contact through all modes of exposure. LPS compounds are highly pyrogenic. Avoid accidental injection; extreme care should be taken when handling in conjunction with hypodermic syringes. Use must be restricted to qualified personnel.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria: Pellegrini, J. M., Keriel, A., et al.; J. Clin. Invest. 135, e182467 (2025), Abstract
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors: Zhivaki, D., Kennedy, S. N., et al.; Cell 187, 3888 (2024), Abstract
Non-canonical NF-κB signaling limits the tolerogenic β-catenin-Raldh2 axis in gut dendritic cells to exacerbate intestinal pathologies: Deka, A., Kumar, N., et al.; EMBO J. 43, 3895 (2024), Abstract
Optimized method for higher yield of alveolar macrophage isolation for ex vivo studies: Devkota, S. P., Onah, C., et al.; Heliyon 10, e37221 (2024), Abstract
Development and optimization of a diluted whole blood ELISpot assay to test immune function: Ungaro, R. F., Xu, J., et al.; bioRxiv , (2024)
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter: Di Gioia, M., Poli, V., et al.; bioRxiv , (2023)
AMPK integrates metabolite and kinase-based immunometabolic control in macrophages: I.R. Phair, et al.; Mol. Metab. 68, 101661 (2023), Abstract
Apis mellifera anatoliaca Venom Exerted Anti-Inflammatory Activity on LPS-Stimulated Mammalian Macrophages by Reducing the Production of the Inflammatory Cytokines: S. Sevin, et al.; Appl. Biochem. Biotechnol. 195, 3194 (2023), Abstract
Immune activation of vaginal human Langerhans cells increases susceptibility to HIV-1 infection: N.H.V. Teijlingen, et al.; Sci. Rep. 13, 3283 (2023), Abstract
Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS: Clénet, M. L., Keaney, J., et al.; Front. Immunol. 14, 1190219 (2023), Abstract

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LPS from E. coli, Serotype O55:B5 (TLRGRADE^®) (Ready-to-Use)

ALX-581-013

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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LPS from E. coli, Serotype O55:B5 (TLRGRADE®) (Ready-to-Use)

ALX-581-013

Product Details

Handling & Storage

Related Products

LPS from E. coli, Serotype R515 (Re) (TLRGRADE®) (Ready-to-Use)

ALX-581-007

LPS from Salmonella minnesota R595 (Re) (TLRGRADE®) (Ready-to-Use)

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LPS from E. coli, Serotype EH100 (Ra) (TLRGRADE®) (Ready-to-Use)

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LPS from E. coli, Serotype J5 (Rc) (TLRGRADE®) (Ready-to-Use)

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Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

LPS from E. coli, Serotype O55:B5 (TLRGRADE^®) (Ready-to-Use)

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