Home Shop Loxoribine

Loxoribine

Already have an account?

TLR ligand

Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Alternative Name	7-Allyl-8-oxoguanosine, RWJ 21757
Appearance	White to off-white solid.
CAS	121288-39-9
Couple Target	TLR, TLR7
Couple Type	Ligand
Formula	C₁₃H₁₇N₅O₆
MW	339.3
Purity	≥97% (HPLC (UV))
Solubility	Soluble in DMSO (30mg/ml), water (10mg/ml), water:acetonitrile (1:1) (20mg/ml) or water:methanol (1:1) (10mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CD163+ M2 Macrophages Promote Fibrosis in IgG4-Related Disease Via Toll-like Receptor 7/Interleukin-1 Receptor-Associated Kinase 4/NF-κB Signaling: Chinju, A., Moriyama, M., et al.; Arthritis Rheumatol. 74, 892 (2022), Abstract
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases: A. Kanno, et al.; Nat. Commun. 6, 6119 (2015), Application(s): Cell Culture, Abstract
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN: I.B. Bekeredjian-Ding, et al.; J. Immunol. 174, 4043 (2005), Abstract — Full Text
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7: J. Lee, et al.; PNAS 100, 6646 (2003), Abstract — Full Text
The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell. Immunol. 162, 333 (1995), Abstract
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle: M.G. Goodman, et al.; Blood 84, 3457 (1994), Abstract — Full Text
Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression: U. Schindler and V.R. Baichwal; Mol. Cell. Biol. 14, 5820 (1994), Abstract — Full Text
Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol. 151, 3007 (1993), Abstract

Datasheet, Manuals, SDS & CofA

Please enter the lot number as featured on the product label

Lot No. :

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form