Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE^®) (Ready-to-Use)

Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice.

TLR, TLR4

Activator, Ligand

Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.

≥99.9% (regarding protein or DNA contaminants; KDO not detectable)

Isolated from Salmonella minnesota R595 (Re mutant). Prepared by mild acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method), converted to the uniform salt form and dissolved in sterile pyrogen-free double distilled water.