Limonin

ALX-350-225

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Carcinogenesis inhibitor

Bitter principle of citrus fruits. Inhibits chemically induced carcinogenesis. Inhibits HIV-1 replication. Shows antinociceptive effect. Does not possess any inherent antioxidant activity.

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Product Details

Alternative Name	Limonoic acid di-δ-lactone
Appearance	White to off-white solid.
CAS	1180-71-8
Formula	C₂₆H₃₀O₈
MI	14: 5494
MW	470.5
Purity	≥98% (UHPLC)
Solubility	Soluble in 100% ethanol or glacial acetic acid; slightly soluble in water.
Source	Isolated from grapefruit seed.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Evaluation of Physiological Activities of the Citron (Citrus junos Sieb. ex TANAKA) Seed Extracts: Kim, S. Y., Shin, K. S., et al.; Prev. Nutr. Food Sci. 18, 196 (2013), Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006), Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003), Abstract
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats: T. Tanaka, et al.; Biofactors 13, 213 (2000), Abstract
Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri: H. Matsuda, et al.; Planta Med. 64, 339 (1998), Abstract
Inhibition of Chemically Induced Carcinogenesis by Citrus Limonoids: L.K.T. Lam, et al.; ACS Symposium Series 546, 209 (1994), Abstract
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989), Abstract
Antifeedant effects of nomilin on Spodoptera frugiperda and Trichoplusia ni under laboratory conditions: M.A. Altieri, et al.; Protect. Ecol. 6, 91 (1984)
Citrus limonoid by-products as insect control agents: J.A. Klocke & I. Kubo; Ent. Exp. & Appl. 32, 299 (1982), Abstract
Nomilin, a new bitter component in grapefruit juice: R.L. Rouseff; J. Agric. Food Chem. 30, 504 (1982), Abstract

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Limonin

ALX-350-225

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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