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LIGHT (soluble) (human), (recombinant)

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Alternative Name	HVEML, TNFSF 14, CD258
Application Notes	ELISA: binds to HVEM receptor at 1-10 ng/ml.
Concentration	0.1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Associates of Cape Cod).
Formulation	Lyophilized. Contains PBS.
MW	~25kDa (SDS-PAGE)
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Source	Produced in HEK 293 cells. The extracellular domain of human LIGHT (aa 89-240) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG^®-tag.
Specificity	Binds to human and mouse LTβR and human HVEM and DcR3.
Technical Info / Product Notes	Historical data shows that the biological activity of LIGHT increases LNCaP (prostate cancer cell) growth. FLAG is a registered trademark of Sigma-Aldrich Co.
UniProt ID	O43557

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Inhibition of LTβR signalling activates WNT-induced regeneration in lung: Conlon, T. M., John-Schuster, G., et al.; Nature 588, 151 (2020), Abstract
Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling: S.F. Dwyer, et al.; Int. J. Biol. Sci. 11, 404 (2015), Application(s): Cell Culture, Abstract — Full Text
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway: N. Nadiminty, et al.; BBRC 359, 379 (2007), Abstract
A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator: L.C. Gonzalez, et al.; PNAS 102, 1116 (2005), Abstract — Full Text
Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis: J. Kuai, et al.; J. Biol. Chem. 278, 14363 (2003), Abstract — Full Text
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001), Abstract

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