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Licochalcone A (synthetic)

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Inhibitor of Bcl-2 expression

Reduces Bcl-2 protein expression.

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Alternative Name	(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
Appearance	Yellow crystalline solid.
CAS	58749-22-7
Formula	C₂₁H₂₂O₄
Identity	Identity determined by NMR.
MW	338.4
Purity	≥96% (HPLC)
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 6 months when stored at 20°C. Dilute stock solution 1:10 with aqueous buffer or medium just prior to use.
Handling	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes: D. Grenier, et al.; AMB Express 10, 120 (2020), Abstract
Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells: Szliszka, E., Jaworska, D., et al.; Int. J. Mol. Sci. 13, 15343 (2012), Abstract

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