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Leukotriene D4

BML-LD004

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Prostanoid receptor ligand

Potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Biosynthesis from LTC4 by γ-glutamyltranspeptidase.

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Product Details

Alternative Name	LTD4
Appearance	Liquid.
CAS	73836-78-9
Couple Target	Leukotriene receptor, Prostanoid receptor
Couple Type	Ligand
Formula	C₂₅H₄₀N₂O₆S
Formulation	Solution in methanol/ammonium acetate buffer, 70:30, pH 5.6.
MW	496.7
Purity	≥98% (HPLC)
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Cysteinyl leukotrienes in asthma: old mediators up to new tricks: D. W. P. Hay, et al.; Trends Pharmacol. 16, 304 (1995), Abstract
Leukotrienes and inflammation: S. D. Brain & T. J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract
The signal transduction system of the leukotriene D4 receptor: S. T. Crooke, et al.; Trends Pharmacol. Sci. 10, 103 (1989), Abstract
Leukotrienes as mediators of ischemia and shock: A. M. Lefer, et al.; Biochem. Pharmacol. 35, 123 (1986), Abstract
Metabolism of leukotrienes: S. Hammarström, et al.; Mol. Cell Biochem. 69, 7 (1985), Abstract

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Leukotriene D4

BML-LD004

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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