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Leukotriene C4

BML-LC004

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Prostanoid receptor ligand

A cysteinyl leukotriene which acts as potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Stimulates angiogenesis. Stimulates LH8, LHRH9 and prolactin release. Produced in specific cell types or by transcellular biosynthesis and rapidly metabolized to LTD4 and LTE4. Transported by the multidrug resistance protein (MRP; K_m=35nM).

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Product Details

Alternative Name	LTC4, 5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
Appearance	Colorless solution.
CAS	72025-60-6
Couple Target	Leukotriene receptor, Prostanoid receptor
Couple Type	Ligand
Formula	C₃₀H₄₇N₃O₉S
Formulation	A solution in ethanol.
MI	14: 5455
MW	625.8
Purity	≥95% (HPLC)
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air. Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of stock solutions may be evaporated to near dryness under a stream of nitrogen and dissolved in ethanol. Stock solutions may be used directly for HPLC analysis.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter: S. Paul et al.; Proc. Natl. Acad. Sci. USA 93, 6929 (1996), Abstract
Cysteinyl leukotrienes in asthma: old mediators up to new tricks: D.W. Hay et al.; Trends Pharmacol. Sci. 16, 304 (1995), Abstract
Leukotriene C4 receptors on guinea pig tracheocytes: S. Prie et al.; J. Pharmacol. Exp. Ther. 274, 312 (1995), Abstract
Leukotrienes and inflammation: S.D. Brain & T.J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract
Transcellular biosynthesis of eicosanoids: J. Maclouf et al.; Pharmacol. Res. 21, 1 (1989), Abstract
Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes: S.J. Feinmark & P.J. Cannon; J. Biol. Chem. 261, 16466 (1986), Abstract
Leukotrienes as mediators of ischemia and shock: A.M. Lefer; Biochem. Pharmacol. 35, 123 (1986), Abstract
Metabolism of leukotrienes: S. Hammarstrom et al.; Mol. Cell Biochem. 69, 7 (1985), Abstract
Leukotrienes and the cardiovascular system: G. Feuerstein; Prostaglandins 27, 781 (1984), Abstract