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Leukotriene B4 antagonist. Inhibits binding of [3H]-LTB4 to guinea pig lung membranes (Ki=0.13 µM). Antagonizes the degranulation response to LTB4 in rabbit PMNL (Kd=0.2 µM) acting, most likely, via receptor desensitization. Partial agonist at higher concentrations (5 µM).
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| Regulatory Status |
RUO – Research Use Only |
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