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Leukotriene B4

BML-LB004

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Prostanoid receptor ligand

Activator of PPARα. Stimulates leukocyte functions including chemokinesis, chemotaxis, lysosomal enzyme release, adhesion, stimulation of ion fluxes, superoxyde anion production and C3b receptor expression. Induces vascular permeability, NK cell activity, and broncho-constriction. UVmax: 270 nm (50,000).

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Product Details

Alternative Name	LTB4, 5,12-Dihydroxy-[S-[R,S-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
Appearance	Colorless liquid.
CAS	71160-24-2
Couple Target	Leukotriene receptor, PPAR, Prostanoid receptor
Couple Type	Activator, Ligand
Formula	C₂₀H₃₂O₄
Formulation	Oil dissolved in ethanol.
MI	14: 5455
MW	336.5
Purity	≥97% (HPLC)
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -80°C.
Handling	Open ampule and aliquot into suitable tubes or vials. Store at -80°C or colder. For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media. For HPLC, aliquots of ethanol solutions should be evaporated to dryness under a stream of nitrogen and HPLC mobile phase added to the desired concentration.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Ligand selectivity of the peroxisome proliferator-activated receptor alpha: Q. Lin et al.; Biochemistry 38, 185 (1999), Abstract
The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells: M. Heimburger & J. Palmblad; Biochem. Biophys. Res. Commun. 249, 371 (1998), Abstract
Leukotriene B4: S.W. Crooks & R.A. Stockley; nt. J. Biochem. Cell Biol. 30, 173 (1998), Abstract
The PPARalpha-leukotriene B4 pathway to inflammation control: P.R. Devchand et al.; Nature 384, 39 (1996), Abstract
Quantitative gas chromatography-mass spectrometry analysis of leukotriene B4: W.R. Mathews; Methods Enzymol. 187, 76 (1990), Abstract
Leukotriene B4 in inflammation: A.W. Ford-Hutchinson; Crit. Rev. Immunol. 10, 1 (1990), Abstract
Leukotrienes and inflammation: S.D. Brain & T.J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract
Biosynthesis and biological activity of leukotriene B4: P. Borgeat & P.H. Naccache; Clin. Biochem. 23, 459 (1990), Abstract
Leukotrienes and the immune system: M. Rola-Pleszczynski; J. Lipid Mediat. 1, 149 (1989), Abstract
Leukotriene B4 and inflammatory disease: R.M. McMillan & S.J. Foster; Agents Actions 24, 114 (1988), Abstract

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Leukotriene B4

BML-LB004

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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