Leptin super antagonist (mutant D23L/L39A/D40A/F41A) (human), (recombinant)

Super human leptin antagonist is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Super human leptin antagonist also inhibits various leptin effects in several in vitro bioassays. The inhibitory activity of super human leptin antagonist was increased 14 to 60 fold as measured by various criteria such as binding properties to human leptin binding domain (hLBD) and in vitro and in vivo bioassays.

< 0.1 ng/µg of protein (<1EU/µg)

Lyophilized.

16.0 kDa

> 98.0% as determined by Gel filtration and SDS-PAGE gel.

Produced in E. coli.

P41159