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Ultra-pure; inhibits actin polymerization
Inhibits actin polymerization, microfilament organzation and microfilament-mediated processes. Acts via a different mechanism and 10- to 20-fold more potently than cytochalasins. Inhibits phagocytosis by macrophages. Exposure to 0.2 mg/ml for one hour produces maximal change in cell morphology.
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Product Details
| Appearance |
White to yellow waxy solid. |
|---|---|
| CAS |
76343-93-6 |
| Formula |
C22H31NO5S |
| MI |
14: 5378 |
| MW |
421.6 |
| Purity |
≥95% (HPLC) |
| Solubility |
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| Technical Info / Product Notes |
Note: Product is not sterile. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression: Zhan, H., Pal, D. S., et al.; Nat. Commun. 16, 5563 (2025), Abstract
- Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration: Lin, Y., Pal, D. S., et al.; Nat. Cell Biol. 26, 1062 (2024), Abstract
- Recessive TMOD1 mutation causes childhood cardiomyopathy: C. Vasilescu, et al.; Commun. Biol. 7, 7 (2024), Abstract
- Self-organizing glycolytic waves fuel cell migration and cancer progression: Zhan, H., Pal, D. S., et al.; bioRxiv , (2024)
- Prolonged depletion of profilin 1 or F-actin causes an adaptive response in microtubules: Cisterna, B. A., Skruber, K., et al.; J. Cell Biol. 223, (2024), Abstract
- Leep2A and Leep2B function as a RasGAP complex to regulate macropinosome formation: Chao, X., Yang, Y., et al.; J. Cell Biol. 223, (2024), Abstract
- Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic: Ramos, M., Martin-Garcia, R., et al.; iScience 27, 110477 (2024), Abstract
- Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein: Zhang, C., Schekman, R., et al.; Elife 12, (2023), Abstract
- Spatially distinct inputs modulate the amount of active Mitotic-phase GAP to locally restrict RhoA signaling for successful cell division: Wolff, F., Srinivasan, S., et al.; bioRxiv , (2023)
- A dynamic partitioning mechanism polarizes membrane protein distribution: Banerjee, T., Matsuoka, S., et al.; Nat. Commun. 14, 7909 (2023), Abstract
- Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics: Holland, S. M., Gallo, G., et al.; J. Cell Sci. 136, (2023), Abstract
- Cytoskeletal adaptation following long-term dysregulation of actomyosin in neuronal processes: Cisterna, B. A., Skruber, K., et al.; bioRxiv , (2023)
- Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and Vop: E. Kudryashova, et al.; Sci. Adv. 8, eadc9239 (2022), Abstract
- Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis: T. Mentrup, et al.; Nat. Commun. 13, 1880 (2022), Abstract
- Gradients of PI(4,5)P2 and PI(3,5)P2 Jointly Participate in Shaping the Back State of Dictyostelium Cells: Li, D., Sun, F., et al.; Front Cell Dev Biol 10, 835185 (2022), Abstract
- Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration: Banerjee, T., Biswas, D., et al.; Nat. Cell Biol. 24, 1499 (2022), Abstract
- Cell patterning by secretion-induced plasma membrane flows: Gerganova, V., Lamas, I., et al.; Sci. Adv. 7, eabg6718 (2021), Abstract
- Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis: Yang, Y., Li, D., et al.; J. Cell Biol. 220, (2021), Abstract
- RhoA- and Cdc42-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes: Dehapiot, B., Clément, R., et al.; PLoS Biol. 19, e3001376 (2021), Abstract
- Actin-dependent membrane polarization reveals the mechanical nature of the neuroblast polarity cycle: LaFoya, B., Prehoda, K. E., et al.; Cell Rep. 35, 109146 (2021), Abstract
- Genetic Suppression of Defective Profilin by Attenuated Myosin II Reveals a Potential Role for Myosin II in Actin Dynamics in vivo in fission yeast: P. Zambon, et al.; Mol. Biol. Cell 31, 2107 (2020), Abstract — Full Text
- An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells: Zhan, H., Bhattacharya, S., et al.; Dev. Cell 54, 608 (2020), Abstract
- Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast: Berglund, L. L., Hao, X., et al.; Sci. Rep. 7, 11328 (2017), Abstract
- Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus: Materne, P., Vázquez, E., et al.; Elife 5, (2016), Abstract
- Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks: Artemenko, Y., Axiotakis, L., et al.; PNAS 113, E7500 (2016), Abstract
- Calcium-mediated actin reset (CaAR) mediates acute cell adaptations: P. Wales, et al.; eLife 5, e19850 (2016), Abstract — Full Text
- GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation: N. Fine, et al.; J. Cell. Biol. 215, 107 (2016), Application(s): Cell treatment, mouse neutrophils, Abstract — Full Text
- Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking: F. O. Bendezú, et al.; PLoS One 31, e1002097 (2015), Application(s): Cell Culture, Abstract — Full Text
- Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep. 5, 9475 (2015), Application(s): Cell Culture, Abstract — Full Text
- Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One 10, e0125119 (2015), Application(s): Cell Culture, Abstract — Full Text
- Filopodia-based Wnt transport during vertebrate tissue patterning: Stanganello, E., Hagemann, A. I., et al.; Nat. Commun. 6, 5846 (2015), Abstract
- Septin-Dependent Assembly of the Exocyst Is Essential for Plant Infection by Magnaporthe oryzae: Gupta, Y. K., Dagdas, Y., et al.; Plant Cell 27, 3277 (2015), Abstract
- Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel: H. Sun, et al.; Sci. Rep. 4, 4934 (2014), Abstract — Full Text
- Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner: Burkard, C., Verheije, M. H., et al.; PLoS Pathog. 10, e1004502 (2014), Abstract
- NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions: Seldin, L., Poulson, N. D., et al.; Mol. Biol. Cell 24, 3651 (2013), Abstract
- The nucleus of endothelial cell as a sensor of blood flow direction: E. Tkachenko, et al.; Biol. Open 2, 1007 (2013), Abstract — Full Text
- Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment: W. Nimlamool, et al.; Mol. Reprod. Dev. 80, 488 (2013), Abstract
- The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes: Nogalski, M. T., Chan, G. C., et al.; PLoS Pathog. 9, e1003463 (2013), Application(s): In Vitro, Abstract
- Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One 8, e72886 (2013), Abstract — Full Text
- Motor-driven motility of fungal nuclear pores organizes chromosomes and fosters nucleocytoplasmic transport: Steinberg, G., Schuster, M., et al.; J. Cell Biol. 198, 343 (2012), Abstract
- The SET domain protein, Set3p, promotes the reliable execution of cytokinesis in Schizosaccharomyces pombe: Rentas, S., Saberianfar, R., et al.; PLoS One 7, e31224 (2012), Abstract
- A role for hippocampal actin rearrangement in object placement memory in female rats: B.S. Nelson, et al.; Neurobiol. Learn. Mem. 98, 284 (2012), Abstract
- Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins: F.Y. Shaikh, et al.; PLoS One 7, e40826 (2012), Abstract — Full Text
- Spatial coordination between cell and nuclear shape within micropatterned endothelial cells: Versaevel, M., Grevesse, T., et al.; Nat. Commun. 3, 671 (2012), Abstract
- A conserved histone deacetylase with a role in the regulation of cytokinesis in Schizosaccharomyces pombe: Grewal, C., Hickmott, J., et al.; Cell Div. 7, 13 (2012), Abstract
- Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission: Cortés, J. C., Sato, M., et al.; J. Cell Biol. 198, 637 (2012), Abstract
- Glioblastoma motility occurs in the absence of actin polymer: A. Panopoulos, et al.; Mol. Biol. Cell 22, 2212 (2011), Abstract — Full Text
- Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain: Saberianfar, R., Cunningham-Dunlop, S., et al.; PLoS One 6, e24694 (2011), Abstract
- Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK: P. Qiu, et al.; FASEB J. 25, 1815 (2011), Abstract — Full Text
- Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway: de Vries, E., Tscherne, D. M., et al.; PLoS Pathog. 7, e1001329 (2011), Abstract
- Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35: Kälin, S., Amstutz, B., et al.; J. Virol. 84, 5336 (2010), Abstract
- Regulation of Distinct Septin Rings in a Single Cell by Elm1p and Gin4p Kinases: B.S. DeMay, et al.; Mol. Biol. Cell 20, 2311 (2009), Abstract
- Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod: Rossy, J., Schlicht, D., et al.; PLoS One 4, e5403 (2009), Abstract
- Latrunculin A depolarizes starfish oocytes: F. Moccia; Comp. Biochem. Physiol. A Mol. Integr. Physiol. 148, 845 (2007), Abstract
- Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A: A. Vazquez-Lopez; Neurosci. Lett. 388, 81 (2005), Abstract
- Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis: J. Wang, et al.; Cell Motil. Cytoskeleton 62, 35 (2005), Abstract
- The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae: F. Reggiori, et al.; Mol. Biol. Cell 16, 5843 (2005), Abstract
- High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A: K.R. Ayscough, et al.; J. Cell Biol. 137, 399 (1997), Abstract — Full Text
- Latrunculins–novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13, 127 (1989), Abstract
- Latrunculin A is a potent inhibitor of phagocytosis by macrophages: C.A. de Oliveira and B. Mantovani; Life Sci. 43, 1825 (1988), Abstract
- Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213, 316 (1987), Abstract
- Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166, 191 (1986), Abstract
- Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983), Abstract
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