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Lamotrigine

ALX-430-160

16 citations

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ALX-430-160-M025 — 25 mg

$219.00

Lamotrigine quantity
ALX-430-160-M100 — 100 mg

$618.00

Lamotrigine quantity
ALX-430-160-M500 — 500 mg

$2,036.00

Lamotrigine quantity

Na⁺ channel blocker

Lamotrigine blocks voltage-gated sodium channels. Inhibits the release of glutamate. Neuroprotective. Anticonvulsant.

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Product Details

Alternative Name	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine, LTG, BW-430C
Appearance	White to off-white powder.
CAS	84057-84-1
Couple Target	Sodium channel
Couple Type	Blocker
Formula	C₉H₇Cl₂N₅
Identity	Determined by IR.
MI	14: 5353
MW	256.1
Purity	≥98% (Assay)
RTECS	XY5850700
Solubility	Soluble in DMSO (60°C, 20mg/ml) or dimethyl formamide; slightly soluble in anhydrous ethanol or dilute hydrochloric acid; almost insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy: C. Luna-Tortos, et al.; Neuropharmacology 58, 1019 (2010), Abstract
Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy: G. Papazisis, et al.; Int. J. Neuropsychopharmacol. 11, 321 (2008), Abstract
Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice: E. Lagrue, et al.; Pediatr. Res. 62, 14 (2007), Abstract
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders: S. Malik, et al.; Expert Rev. Neurother. 6, 1609 (2006), Abstract
A novel drug binding site on voltage-gated sodium channels in rat brain: D.R. Ridall, et al.; Mol. Pharmacol. 69, 278 (2006), Abstract — Full Text
Lamotrigine in the treatment of bipolar disorder: Z. Bhagwagar & G.M. Goodwin; Expert Opin. Phamacother. 6, 1401 (2005), Abstract
Review of lamotrigine and its clinical applications in epilepsy: H. Choi & M.J. Morrell; Expert Opin. Pharmacother. 4, 243 (2003), Abstract
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception: T.M. Laughlin, et al.; J. Pharmacol. Exp. Ther. 302, 1168 (2002), Abstract — Full Text
A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group: J.R. Calabrese, et al.; J. Clin. Psychiatry 60, 79 (1999), Abstract
Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder: X. Xie & R.M. Hagan; Neuropsychobiology 38, 119 (1998), Abstract

Last modified: May 29, 2024

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Lamotrigine

ALX-430-160

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