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L-NMMA . monoacetate

ALX-106-001

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ALX-106-001-M025 — 25 mg

$77.00

L-NMMA . monoacetate quantity
ALX-106-001-M100 — 100 mg

$278.00

L-NMMA . monoacetate quantity
ALX-106-001-G001 — 1 g

$445.00

L-NMMA . monoacetate quantity

NOS inhibitor

Competitively inhibits the generation of NO from arginine and is a useful tool for inhibition of NO mediated effects. In vitro, L-NMMA inhibits relaxation of rat aorta rings induced by acetylcholine (IC₅₀=9.5µM). In vivo, it causes a dose dependent increase in mean arterial blood pressure in anesthetized rats (EC₅₀=16.7mg/kg).

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Product Details

Alternative Name	NG-Monomethyl-L-arginine . monoacetate
Appearance	White to off-white solid.
CAS	53308-83-1
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₇H₁₆N₄O₂ . CH₃COOH
MW	188.2 . 60.1
Purity	≥99% (TLC)
Solubility	Soluble in water, 100% ethanol (1mg/ml) or DMSO (0.25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities: K.M. Do, et al.; Phytochemistry 205, 113510 (2023), Abstract
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells: J.S. Stancill, et al.; Function (Oxf.) 3, zqab063 (2022), Abstract
Marginols A‒H, unprecedented pimarane diterpenoids from Kaempferia marginata and their NO inhibitory activities: K.M. Do, et al.; Phytochemistry 196, 113109 (2022), Abstract
Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives: C.M.H. Anderson, et al.; Biomolecules 12, 1404 (2022), Abstract
Regulation of ATR-dependent DNA damage response by nitric oxide: C.T. Yeo, et al.; J. Biol. Chem. 296, 100388 (2021), Abstract
Antibodies against invasive phenotype-specific antigens increase Mycobacterium avium subspecies paratuberculosis translocation across a polarized epithelial cell model and enhance killing by bovine macrophages: Everman, J. L., Bermudez, L. E., et al.; Front. Cell. Infect. Microbiol. 5, 58 (2015), Abstract
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg. 141, 425 (2011), Abstract — Full Text
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004), Abstract — Full Text
Nitric oxide: an endogenous modulator of leukocyte adhesion: P. Kubes, et al.; PNAS 88, 4651 (1991), Abstract
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo: D.D. Rees, et al.; Br. J. Pharmacol. 101, 746 (1990), Abstract

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L-NMMA . monoacetate

ALX-106-001

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