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L-NIL . dihydrochloride

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NOS inhibitor

Selective inhibitor of inducible nitric oxide synthase (iNOS; NOS II). Shows anti-inflammatory activity.

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Alternative Name	L-N6-(1-Iminoethyl)-lysine . 2HCl
Appearance	White to off-white solid.
CAS	159190-45-1
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₈H₁₇N₃O₂ . 2HCl
MW	187.2 . 73.0
Purity	≥97% (TLC)
Solubility	100mg/ml soluble in water or methanol.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

c-Myc inhibition is critical for HSC expansion and Rad51 expression: Aksoz, M., Albayrak, E., et al.; bioRxiv , (2018)
Ligation of CD40 in Human Müller Cells Induces P2X7 Receptor-Dependent Death of Retinal Endothelial Cells: JC. Portillo, et al.; Invest. Ophthalmol. Vis. Sci. 1, 6278 (2016), Abstract — Full Text
Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression: Fritsche, G., Nairz, M., et al.; J. Leukoc. Biol. 92, 353 (2012), Abstract
Adiponectin is a potential catabolic mediator in osteoarthritis cartilage: E.H. Kang, et al.; Arthritis Res. Ther. 12, R231 (2010), Abstract — Full Text
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors: D. Salvemini, et al.; J. Clin. Invest. 96, 301 (1995), Abstract
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase: W.M. Moore, et al.; J. Med. Chem. 37, 3886 (1994), Abstract

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