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L-Mimosine

BML-CC102

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Cell cycle blocker

A rare plant amino acid that reversibly blocks the cell cycle at G1-phase. Inhibits the hydroxylation of deoxyhypusine and thus inhibits eukaryote initiation factor 5-A (eIF5-A). Inhibitor of mammalian tyrosinase and dopamine β-hydroxylase. Also chelates iron via the kojic acid metal-binding domain. Arrests DNA synthesis by inhibiting deoxyribonucleotide metabolism.

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Product Details

Appearance	Pink to brown powder.
CAS	500-44-7
Couple Target	Dopamine beta-hydroxylase, eIF, Tyrosinase
Couple Type	Inhibitor
Formula	C₈H₁₀N₂O₄
Identity	Determined by 1H-NMR.
MW	198.2
Purity	≥98%
Solubility	Soluble in 10% sodium bicarbonate (15mg/ml)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents: M.D. Pelegrini, et al.; Asian. Pac. J. Trop. Med. 9, 652 (2016), Application(s): Cell culture, Abstract
Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism: D. M. Gilbert et al.; J. Biol. Chem. 270, 9597 (1995), Abstract
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation: H. M. Hanauske-Abel et al.; Biochim. Biophys. Acta. 1221, 115 (1994), Abstract
A general protocol for evaluating the specific effects of DNA replication inhibitors: V. Levenson et al.; Nucleic. Acids. Res. 21, 3997 (1993), Abstract
Inhibition of two copper-containing enzymes, tyrosinase and dopamine beta-hydroxylase, by L-mimosine: H. Hashiguchi & H. Takahashi; Mo Pharmacol. 13, 362 (1977), Abstract

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L-Mimosine

BML-CC102

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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