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L-AP4

ALX-550-026

9 citations

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mGluR agonist

Selective agonist for group III mGluRs. NMDA agonist. Potent synaptic depressant.

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Product Details

Alternative Name	L(+)-2-Amino-4-phosphonobutanoic acid
Appearance	White crystalline powder.
CAS	23052-81-5
Couple Target	Metabotropic glutamate receptor, NMDA receptor
Couple Type	Activator, Ligand
Formula	C₄H₁₀NO₅P
MW	183.1
Purity	≥97% (HPLC)
Solubility	Soluble in dilute aqueous base.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective glycinergic input from vGluT3 amacrine cells confers a suppressed-by-contrast trigger feature in a subtype of M1 ipRGCs in the mouse retina: Lee, S., Chen, M., et al.; J. Physiol. 599, 5047 (2021), Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate: Y. Nakajima, et al.; J. Biol. Chem. 268, 11868 (1993), Abstract — Full Text
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase: C. Thomsen, et al.; Eur. J. Pharmacol. 227, 361 (1992), Abstract
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor: P.Q. Trombley and G.L. Westbrook; J. Neurosci. 12, 2043 (1992), Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990), Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & J.C. Watkins; Brain Res. 235, 378 (1982), Abstract
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex: J.F. Koerner & C.W. Cotman; Brain Res. 216, 192 (1981), Abstract

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L-AP4

ALX-550-026

Product Details

Handling & Storage

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