L-AP3

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mGluR antagonist

Selective antagonist of the PI-linked metabotropic glutamate response.

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Alternative Name	L(+)-2-Amino-3-phosphonopropanoic acid
Appearance	White hygroscopic solid.
CAS	23052-80-4
Couple Target	Metabotropic glutamate receptor
Couple Type	Inhibitor, Ligand
Formula	C₃H₈NO₅P
MW	169.1
Purity	≥97%
Solubility	Soluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review), Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation: J.J. O’Connor, et al.; Nature 367, 557 (1994), Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp & P.J. Conn; TIPS 14, 13 (1993), (Review), Abstract
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons: A.J. Irving, et al.; Eur. J. Pharmacol. 186, 363 (1990), Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid: D.D. Schoepp, et al.; Mol. Pharmacol. 38, 222 (1990), Abstract

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