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L-858051

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Adenylate cyclase activator

A water-soluble forskolin derivative, retaining adenylate cyclase stimulatory activity (EC₅₀=10 µM).

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells: M. Belacel-Quari, et al.; Cell. Signal. 35, 118 (2017), Abstract
Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4: Hubert, F., Belacel-Ouari, M., et al.; Br. J. Pharmacol. 171, 5361 (2014), Abstract
Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells: S. F. Luo, et al.; Cell. Signal. 9, 159 (1997), Abstract
Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides: J. N. Lorenz, et al.; Am. J. Physiol. 266, C1656 (1994), Abstract
Stimulation of adenylate cyclase by water-soluble analogues of forskolin: A. Laurenza,et al.; Mol. Pharmacol. 32, 133 (1987), Abstract

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