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L-α-Phosphatidylinositol-3,4-P2

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Activator of PKC and Akt

Activates Ca²⁺-insensitive PKC isotypes δ, ε and η. Activates Akt/PKB by direct interaction with the Akt PH domain.

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Appearance	White solid.
Couple Target	Akt, PKC
Couple Type	Activator
Formula	C₄₁H₇₆O₁₉P₃ . 5NH₄
MW	966.0 . 90.2
Purity	≥98% (NMR)
Solubility	Soluble in chloroform/methanol/water, 50:50:10 (10mg/ml); not water soluble but resuspends, with vigorous vortexing, to ~0.5 mg/ml in water. See references for method of incorporation into mixed lipid vesicles by sonication, and for dissolving in a detergent-containing buffer.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate: T.F. Franke, et al.; Science 275, 665 (1997), Abstract
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K. Klarlund, et al.; Science 275, 1927 (1997), Application(s): Dissolving in a detergent-containing buffer., Abstract
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem. 269, 32358 (1994), Application(s): Method of incorporation into mixed lipid vesicles, Abstract

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