Home Shop L-α-Phosphatidylinositol-3,4,5-P3 . 7Na

L-α-Phosphatidylinositol-3,4,5-P3 . 7Na

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PKC substrate

Activates Ca²⁺-insensitive PKC isotypes δ, ε and η. Binds to GRP1 via a PH domain.

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Alternative Name	PtdIns(3,4,5)P3, (1,2-dipalmitoyl)-, 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate . 7Na
Couple Target	PKC
Couple Type	Substrate
Formula	C₄₁H₇₅O₂₂P₄ . 7Na
Formulation	Lyophilized.
MW	1204.8
Purity	≥98% (TLC)
Solubility	Soluble in water (10mg/ml) or in chloroform/methanol/water (1:1:0.3) (>10mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains: J.K.Klarlund, et al.; Science 275, 1927 (1997), Abstract
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3: A. Toker, et al.; J. Biol. Chem. 269, 32358 (1994), Abstract

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