KT5823

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PKG inhibitor

KT5823 is a derivative of K-252a and is a selective, cell permeable, inhibitor of PKG (K_i=0.234 µM). K_i’s for PKA =4μM and for MLCK=>10μM.

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Appearance	White solid.
CAS	126643-37-6
Couple Target	PKG
Couple Type	Inhibitor
Formula	C₂₉H₂₅N₃O₅
MW	495.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (20mg/ml), dimethyl formamide (20mg/ml) and ethyl acetate (5mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at 4°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions: Paintlia, M. K., Paintlia, A. S., et al.; J. Biol. Chem. 288, 3831 (2013), Abstract
Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons: Mandal, S., Stanco, A., et al.; J. Neurosci. 33, 16897 (2013), Abstract
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases: H. Kase, et al.; Biochem. Biophys. Res. Commun. 142, 436 (1987), Abstract

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