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Koningic acid

ENZ-CHM494

  • ENZ-CHM494-0001   —   1 mg
    $552.00

Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety, for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion. Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.

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Regulatory Status

RUO – Research Use Only