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KN-93 phosphate

ALX-430-127

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CaM kinase II inhibitor

Selective inhibitor of rat brain Ca²⁺/calmodulin-dependent protein kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A (PKA) activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

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Product Details

Alternative Name	KN-93 (water soluble), 2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine . hydrogen phosphate
Appearance	White to off-white solid.
CAS	1188890-41-6
Couple Target	CaM kinase
Couple Type	Inhibitor
Formula	C₂₆H₂₉ClN₂O₄S . H₃PO₄
Identity	Determined by NMR.
MW	501.0 . 98.0
Purity	≥98% (1H-NMR)
Solubility	Soluble in DMSO or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. Hygroscopic.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII: Nitzki, F., Zibat, A., et al.; Cancer Res. 70, 2739 (2010), Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995), Abstract
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993), Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993), Abstract
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991), Abstract

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CAS	139298-40-1
Couple Type	Inhibitor
Purity	≥95% (HPLC)

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KN-93 phosphate

ALX-430-127

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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