KN-93

BML-EI268

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CaM kinase inhibitor

KN-93 is a potent, selective and cell-permeable inhibitor of CaM kinase II (IC₅₀=370 nM). Does not significantly inhibit PKA. Causes cell-cycle arrest in NIH 3T3 fibroblasts and HeLa cells. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

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Product Details

Appearance	white to off-white solid
CAS	139298-40-1
Couple Target	CaM kinase
Couple Type	Inhibitor
Formula	C₂₆H₂₉ClN₂O₄S
MW	501
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receipt. Stock solutions are stale for up to 3 months when stored at -20°C.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol. 321, C549 (2021), Abstract
O GlcNAcylation contributes to intermittent hypoxia associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways: X. Guo, et al.; Mol. Med. Rep. 14, 744 (2021), Abstract
Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway: R. Zhang, et al.; J. Cell Physiol. 232, 2145 (2017), Abstract
From blue light to clock genes in zebrafish ZEM-2S cells: Ramos, B. C., Moraes, M. N., et al.; PLoS One 9, e106252 (2014), Application(s): In Vitro, Abstract
G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R. M. Tombes; Cell Growth. Differ. 6, 1063 (1995), Abstract
Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells: G. Rasmussen & C. Rasmussen; Biochem. Cell Biol. 73, 201 (1995), Abstract
Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya et al.; Biochem. Biophys. Res. Commun. 195, 608 (1993)
Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki et al.; Biochem. Biophys. Res. Commun. 191, 255 (1993), Abstract
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi et al.; Biochem. Biophys. Res. Commun. 181, 968 (1991), Abstract

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KN-93

BML-EI268

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Handling & Storage

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