KN-62

BML-EI230

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CaM kinase inhibitor

KN-62 is a potent and selective inhibitor of Ca²⁺/calmodulin kinase II (K_i=0.9 µM). Causes cells to arrest in S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 µM blocked CaMKII phosphorylation of III-AC and inhibited hormone-stimulated Ca²⁺ oscillations.

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Product Details

Appearance	White to yellow solid.
CAS	127191-97-3
Couple Target	CaM kinase
Couple Type	Inhibitor
Formula	C₃₈H₃₅N₅O₆S₂
Identity	Determined by 1H-NMR.
MW	721.8
Purity	≥98% (TLC)
Solubility	Soluble in methanol and DMSO (50mg/ml)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol. 321, C549 (2021), Abstract
Expression of P2X7R in breast cancer tissue and the induction of apoptosis by the gene-specific shRNA in MCF-7 cells: Tan, C., Han, L. I., et al.; Exp. Ther. Med. 10, 1472 (2015), Abstract
Upregulation of Voltage-Gated Calcium Channel Cav1.3 in Bovine Somatotropes Treated with Ghrelin: V.M. Salinas Zarate, et al.; J. Signal Transduct. 2013, 527253 (2013), Abstract — Full Text
TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes: Gadeock, S., Tran, J. N., et al.; Biochim. Biophys. Acta 1798, 2058 (2010), Abstract
The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types: Stevenson, R. O., Taylor, R. M., et al.; Purinergic Signal. 5, 385 (2009), Abstract
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo: J. Wei et al.; J. Biol. Chem. 271, 24231 (1996), Abstract
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid: P.B. Gordon, et al.; J. Biol. Chem. 270, 5830 (1995), Abstract — Full Text
The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle: H. Minami et al.; Biochem. Biophys. Res. Commun. 199, 241 (1994), Abstract
Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II: R.M. Wenham et al.; Biochem. Biophys. Res. Commun. 189, 128 (1992), Abstract
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells: A. Ishii et al.; Biochem. Biophys. Res. Commun. 176, 1051 (1991), Abstract

Last modified: May 29, 2024

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KN-62

BML-EI230

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