KIM-1 (human) ELISA kit

• Sensitive – reliably measure as little as 1.279 pg/ml of KIM-1
• High Throughput – results in <2 hours from up to 38 samples in duplicate
• Specific – low cross-reactivity to similar proteins
• Quantitative – fully quantitative results for both normal and disease state samples that surpass semi-quantitative Western blot analysis

The KIM-1 (human) ELISA kit is a complete, colorimetric, immunometric immunoassay kit for the quantitative determination of human KIM-1 in urine with results in <2 hours.

Chronic kidney disease (CKD) is a major public health problem, as one in nine American adults have CKD. There have been numerous studies focused on this disease over the years but there remains a need for improved therapeutics and identifying and/or predicting patient outcomes. One protein that has been identified as playing an important role in kidney disease is Kidney Injury Molecule-1 (KIM-1). KIM-1 is a 30KDa, type 1 membrane protein with an ectodomain that contains immunoglobulin and highly O-glycosylated mucin subdomains as well as multiple N-glycosylation sites. It is the most highly upregulated protein in the proximal tubule of the injured kidney. It exists in very low levels in normal kidneys but when upregulated during injury, it is detectable in urine in a wide variety of human diseases. KIM-1 is a potential biomarker for renal injury, which would suggest it has great importance in various kidney diseases and disorders, such as chronic kidney disease (as mentioned above), as well as acute tubular necrosis and acute kidney failure.