Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
Product Details
Alternative Name |
Apo-2L, TNFSF 10, CD253 |
---|---|
Biological Activity |
Induces apoptosis in a concentration range of 10-100ng/ml. |
Endotoxin Content |
<10EU/µg protein (LAL test; Bio Whittaker). |
Formulation |
Liquid. In 20mM HEPES, pH 7.4, containing 150mM sodium chloride, 0.005% Tween 20, 1% sucrose, 1mM DTT. |
Purity |
≥98% (SDS-PAGE) |
Purity Detail |
Affinity purified. |
Reconstitution |
For a special storage and dilution buffer see KillerTRAIL™ Storage and Dilution Buffer (Prod. No. ALX-505-005). |
Source |
Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. |
Specific Activity |
ED50: 20ng/ml (BJAB cells) |
Specificity |
Binds to human and mouse TRAIL receptors and osteoprotegerin (OPG). |
UniProt ID |
P50591 |
Handling & Storage
Handling |
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
---|---|
Long Term Storage |
-80°C |
Shipping |
Dry Ice |
Regulatory Status |
RUO – Research Use Only |
---|
- Exploiting the immunogenic potential of standard of care radiation or cisplatin therapy in preclinical models of HPV-associated malignancies: J.T. Kowalczyk, et al.; J. Immunother. Cancer 11, e005752 (2022), Abstract
- Differences and similarities in TRAIL-and tumor necrosis factor-mediated necroptotic signaling in cancer cells: J. Sosna, et al.; Mol. Cell. Biol. 36, 2626 (2016), Abstract
- The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosis: M. El-Mesery, et al.; Exp. Biol. Med. 241, 2015 (2016), Abstract
- Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1: M. MacFarlane, et al.; Cell Death Differ. 12, 773 (2005), Abstract
- TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors: M. Plasilova, et al.; Leukemia 16, 67 (2002), Abstract
- TRAIL and its receptors in the colonic epithelium: a putative role in the defense of viral infections: J. Sträter, et al.; Gastroenterology 122, 659 (2002), Abstract
- The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein: J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001), Abstract — Full Text
- The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines: Q. Liao, et al.; FEBS Lett. 503, 151 (2001), Abstract
Related Products
SUPERKILLERTRAIL® Protein (soluble) (human), (recombinant)
ALX-201-115
Enhanced ligand with improved stability providing significantly enhanced immune activation.

Alternative Name | TNFSF 10, Apo-2L, CD253 |
---|---|
Purity | ≥98% (SDS-PAGE). MS analysis, <1% impurity (mainly Hsp70 protein from E. coli) |
Source | Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. |

Alternative Name | Apo-2L, TNFSF 10, CD253 |
---|---|
Application | Flow Cytometry, FUNC |
Host | Mouse |
Isotype | IgG1 |
Species Reactivity | Human |
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form