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Kavain is one constituent of kava-kava, an herbal drug of the South Pacific islands, which displays anti-convulsive, anxiolytic, analgesic and muscle relaxing properties. Kavain inhibits voltage-dependent Na+ channels in rat CA1 hippocampal neurons. It displays protective effects in the MPTP mouse model of Parkinson’s disease but potentiates NMDA toxicity in the developing hippocampus.
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