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Kaempferol

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Fatty acid synthase inhibitor

Antioxidant flavonoid. Apoptosis inducer. Reversible inhibitor of fatty acid synthase (FAS).

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Alternative Name	3,4′,5,7-Tetrahydroxyflavone
Appearance	Yellow powder.
CAS	520-18-3
Couple Target	Fatty acid synthase
Couple Type	Inhibitor
Formula	C₁₅H₁₀O₆
MI	14: 5274
MW	286.2
Purity	≥90% (HPLC)
RTECS	LK9275200
Solubility	Soluble in ether or 100% ethanol (hot); slightly soluble in water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis: C.-J. Lee, et al.; Cell Death Dis. 9, 401 (2018), Application(s): Cell culture treatment, Abstract — Full Text
Mechanism of Toona sinensis-stimulated adrenal steroidogenesis in primary rat adrenal cells: Y.C. Chen, et al.; J. Funct. Foods 14, 318 (2015), Application(s): Mass Spectrometry, Cell Culture
Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis: Szliszka, E., Zydowicz, G., et al.; Int. J. Oncol. 38, 941 (2011), Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)–catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review), Abstract
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li & W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003), Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract

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